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KMID : 0362919850030020087
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Journal of the Korean Society for Therapeutic Radiology and Oncology
1985 Volume.3 No. 2 p.87 ~ p.93
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The Effect of Combination of Radiation with 5-Fluorouracil on Mouse Jejunal Crypt Cells
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Huh Seung-Jae
Park Charn-Il
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Abstract
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The interaction of radiation and 5-Fluorouracil (5-FU) on mouse jejunal crypt cells was studied using the microcolony survival assay. 150mg/kg of 5-FU was injected intraperitoneally 15 minutes before irradiation and 6 hours after irradiation. Jejunal crypt cells of mouse survived more when 5-FU was given 15 minutes before irradiation than giving it 6 hours after irradiation.
The mean lethal doses (Do) of each of irradiation alone group, 5-FU injection group of 15 minutes preceding irradiation, and 5-FU injection group of 6 hours post irradiation were. 135, 135, and 114 rad respectively. The dose effect factor (DEF) of each of 5-FU injection groups of 15 minutes preceding irradiation and of 6 hours post irradiation were 1.13 and 1.27.
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KEYWORD
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Radiation, 5-FU, Mouse jejunal crypt, Interaction
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